Publications and Posters

Neural History of Seizures: (Dec 2024) Poster, Wykes et al, AES 2024.

Step Response of Metallic Electrodes: (Nov, 2024) Talk, Hashemi et al, iCSD 2024.

Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo (Apr 2024) Upadhya et al, Brain, doi: 10.1093/brain/awae129.

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy (Sep 20223) Donneger et al, BioRxiv preprint, doi: 10.1101/2023.09.16.557753

Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture (Jan 2023) Muza et al, iScience, doi: 10.1016/j.isci.2023.106073

Specific inhibition of NADPH oxidase 2 modifies chronic epilepsy (Dec 2022) Singh et al, Redox Biol, doi: 10.1016/j.redox.2022.102549.

Early life pain experience changes adult functional pain connectivity in the rat somatosensory and the medial prefrontal cortex (Nov 2022) Chang et al, J. Neurosci, doi: 10.1523/JNEUROSCI.0416-22.2022.

On-demand cell-autonomous gene therapy for brain circuit disorders (Nov 2022) Qui et al, Science, doi: 10.1126/science.abq6656.

Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures (Nov 2021) Kreye et al, J Exp Med, doi: 10.1038/s42003-021-02635-8.

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody- mediated encephalitis (Sep 2021) Wright et al, Commun Biol, doi: 10.1038/s42003-021-02635-8.

Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation (Mar 2021) Gonzalez-Sulzer et al, Brain, doi.10.1093/brain/awab051.

The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects (Nov 2020) Broekaart et al, J Clin Invest, doi: 10.1172/JCI138332.

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome (Jan 2020) Chang et al, Cell Rep, doi: 10.1016/j.celrep.2019.12.065.

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy (Sep 2019) Shekh-Ahmad et al, Redox Biol, doi: 10.1016/j.redox.2019.101278.

Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression (Jun 2019) Costart et al, Brain Stimul, doi: 10.1016/j.brs.2019.06.009.

Epilepsy Gene Therapy Using an Engineered Potassium Channel (Feb 2019) Snowball et al, J Neurosci, doi: 10.1523/JNEUROSCI.1143-18.2019.

Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model (Nov 2018) Chang et al, Dis Model Mech, doi: 10.1242/dmm.036194.

Biochemical autoregulatory gene therapy for focal epilepsy (Jul 2018) Leib et al, Nat Med, doi: 10.1038/s41591-018-0103-x.

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy (May 2018) Shekh-Ahmad et al, Brain, doi: 10.1093/brain/awy071.

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease (Apr 2018) Brown et al, eNeuro, doi: 10.1523/ENEURO.0426-17.2018.

A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses (May 2017) Rajman et al, EMBO, doi: 10.15252/embj.201695748.

Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline (Jan 2017) Khalil et al, Epilepsia, doi: 10.1111/epi.13645.

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups (Oct 2016) Chang et al, Cereb Cortex, doi: 10.1093/cercor/bhw330.

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model (Aug 2015) Wright et al, Brain, doi: 10.1093/brain/awv257.

Monitoring and analyzing seizure activity in rodents: (Nov 2014) Poster, Wykes et al, SfN 2014.

Measuring seizure susceptibility in mice: (Nov 2014) Poster, Wright et al, SfN 2014.

Chemical-genetic attenuation of focal neocortical seizures (Apr 2014) Kaetzel et al, Nat Commun, doi: 10.1038/ncomms.4847.

Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat (Aug 2013) Goodrich et al, J Neurotrauma, doi: 10.1089/neu.2012.2712.

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy (Nov 2012) Wykes et al, Sci Transl Med, doi: 10.1126/scitranslmed.3004190.

A Novel Telemetry System for Recording EEG in Small Animals (Sep 2011) Chang et al, J Neurosci Methods, doi: 10.1016/j.jneumeth.2011.07.018.