Subcutaneous Transmitter

Figure: Selection of Subcutaneous Transmitters. D: A3049D, dual-channel, 2.6 ml. S: A3048S, single-channel, 0.89 ml. H: A3049H, dual-channel, 1.4 ml. B: A3049B, single-channel, 1.2 ml. The S version equipped with 0.5-mm diameter leads, others with 0.7-mm diameter leads.

System Description

Prospectus: An pamphlet introducing our telemetry system (PDF).
Telemetry Manual: Detailed description of the telemetery system, including set-up instructions, and implantation.
Publications: List of published papers describing studies done with the telemetry system.
Example Recordings: A selection of recordings made with our subcutaneous transmitters.
Mock Interview: Mock interview between a potential telemetry customer and our president.
Real-Time System Setup: Watch us put together a recording system in five minutes.
Parts and Prices: A list of devices and their prices.
Testimonials: Comments from users of our telemetry system.
Forums: Forums for customer support.

Device Manuals

One-Channel SCT (A3048): Small implantable sensor, one biopotential (active).
Two-Channel SCT (A3049): Implantable sensor, two biopotentials (active).
Four-Channel SCT (A3047): Implantable sensor, four biopotentials plus temperature (active).
Two-Channel SCT (A3028): Implantable sensor, two biopotentials (discontinued).
Telemetry Antennas (A3015): Telemetry antenna with coaxial socket (active).
Faraday Enclosures (FEx): Faraday enclosures to block radio-frequency interference (active).
Canopy Feedthrough (A3039): Coaxial and Ethernet feedthroughs for our Faraday canopies (active).
Telemetry Control Box (TCB): Message receiver with PoE interface (active).
Animal Location Tracker (ALT): Message receiver and location tracker with PoE interface (active).
Octal Data Receiver (ODR): Telemetry data receiver (discontinued).
LWDAQ Driver (A2071E): General-purpose data acquisition controller (active).

Software Guides

LWDAQ Software: Network-based data acquisition and analysis software.
Receiver Instrument: Software component that downloads telemetry data.
Neurorecorder Tool: Software component that writes telemetry signals to disk.
Neuroplayer Tool: Software component that reads, analyzes, and translates recorded telemetry signals.
Startup Manager: Software component that starts telemetry with one click.
Recording and Playback: Video introduction to the Neurorecorder and Neuroplayer.
Telemetry and Video: Video introduction to synchronous telemetry, stimulus, and video.

Application Notes

The Source of EEG: The origin of the electroencephalogram signal.
Event Detection: Automatic detection of seizures, spikes, waves, and ripples.
Flexible Wires: Design and selection of leads and antennas for implants.
Electrodes: Design and selection of terminations of leads.
Reception: Measurements of radio-frequency reception reliability.
Mains Hum: The origin of wall power noise.

Selected Publications

Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo (Apr 2024) Upadhya et al, Brain, doi: 10.1093/brain/awae129.
Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture (Jan 2023) Muza et al, iScience, doi: 10.1016/j.isci.2023.106073
Specific inhibition of NADPH oxidase 2 modifies chronic epilepsy (Dec 2022) Singh et al, Redox Biol, doi: 10.1016/j.redox.2022.102549.
Early life pain experience changes adult functional pain connectivity in the rat somatosensory and the medial prefrontal cortex (Nov 2022) Chang et al, J. Neurosci, doi: 10.1523/JNEUROSCI.0416-22.2022.
On-demand cell-autonomous gene therapy for brain circuit disorders (Nov 2022) Qui et al, Science, doi: 10.1126/science.abq6656.
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures (Nov 2021) Kreye et al, J Exp Med, doi: 10.1038/s42003-021-02635-8.
Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody- mediated encephalitis (Sep 2021) Wright et al, Commun Biol, doi: 10.1038/s42003-021-02635-8.
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation (Mar 2021) Gonzalez-Sulzer et al, Brain, doi.10.1093/brain/awab051.
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects (Nov 2020) Broekaart et al, J Clin Invest, doi: 10.1172/JCI138332.
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome (Jan 2020) Chang et al, Cell Rep, doi: 10.1016/j.celrep.2019.12.065.
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy (Sep 2019) Shekh-Ahmad et al, Redox Biol, doi: 10.1016/j.redox.2019.101278.
Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression (Jun 2019) Costart et al, Brain Stimul, doi: 10.1016/j.brs.2019.06.009.
Epilepsy Gene Therapy Using an Engineered Potassium Channel (Feb 2019) Snowball et al, J Neurosci, doi: 10.1523/JNEUROSCI.1143-18.2019.
Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model (Nov 2018) Chang et al, Dis Model Mech, doi: 10.1242/dmm.036194.
Biochemical autoregulatory gene therapy for focal epilepsy (Jul 2018) Leib et al, Nat Med, doi: 10.1038/s41591-018-0103-x.
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy (May 2018) Shekh-Ahmad et al, Brain, doi: 10.1093/brain/awy071.
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease (Apr 2018) Brown et al, eNeuro, doi: 10.1523/ENEURO.0426-17.2018.
A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses (May 2017) Rajman et al, EMBO, doi: 10.15252/embj.201695748.
Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline (Jan 2017) Khalil et al, Epilepsia, doi: 10.1111/epi.13645.
The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups (Oct 2016) Chang et al, Cereb Cortex, doi: 10.1093/cercor/bhw330.
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model (Aug 2015) Wright et al, Brain, doi: 10.1093/brain/awv257.
Chemical-genetic attenuation of focal neocortical seizures (Apr 2014) Kaetzel et al, Nat Commun, doi: 10.1038/ncomms.4847.
Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat (Aug 2013) Goodrich et al, J Neurotrauma, doi: 10.1089/neu.2012.2712.
Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy (Nov 2012) Wykes et al, Sci Transl Med, doi: 10.1126/scitranslmed.3004190.
A Novel Telemetry System for Recording EEG in Small Animals: description of the subcutaneous transmitter system (Sep 2011) Chang et al, J Neurosci Methods, doi: 10.1016/j.jneumeth.2011.07.018.

Archived Documents

Monitoring and analyzing seizure activity in rodents: Poster, Wykes et al, 2014.
Measuring seizure susceptibility in mice: Poster, Wright et al, 2014.
Subcutaneous Transmitter (A3009): Prototype implantable SCT.
Subcutaneous Transmitter (A3013): Successful implantable SCT, magnetic reed switch.
Subcutaneous Transmitter (A3019): Successful implantable SCT, Hall effect switch.
Subcutaneous Transmitter (A3028): Long-running implantable SCT, two inputs.
Data Receiver (A3018): Original data receiver, one antenna input.
Modulating Transmitter: Original feasibility study using our Modulating Transmitter test circuit, 2004.
Downshifting Receiver: Original feasibility study using our Downshifting Receiver test circuit, 2004.
Miniature Transmitter: Original feasibility study using our Miniature Transmitter test circuit, 2004.